It is only after connecting with the vitamin D receptors of special immune system cells, does circulating calcidiol become the cytokine-like calcitriol. Now, we are told that the "Simple vitamin D has now become a biochemical wizard for cytokines" are a category of signaling molecules used extensively in intercellular communication.
Our most important hormones depend upon sufficient reserves of cholesterol for their production. Nowhere is this more essential than as the precursor substance for the synthesis of vitamin D, known also as calcitriol.
The scientists said that a vitamin D precursor is synthesized in the skin from cholesterol in response to absorbing Ultraviolet B rays. It then gets converted in the liver to an intermediate form known as calcidiol. However, in the kidneys it joins with an important enzyme for conversion of the circulating calcidiol into its active hormonal form known as calcitriol. Thus, it is in the immune system that calcidiol changes into its final cytokine state. It is in this cytokine state that enables it to perform a wide variety of anti-inflammatory and immunomodulatory activities.
The Vitamin D Cure
In recent years, the cytokine receptors have caught the attention of more investigators than cytokines themselves.
That is why vitamin D has now become a new biochemical, because it was thought, that vitamin D was important only to calcium, the parathyroid gland and our bones.
Now consider the impact of statin drugs on people that are already overburdened with an epidemic of vitamin D deficiency. Cholesterol must be available in our bodies in amounts sufficient to allow ultraviolet B conversion to vitamin D. People are all genetically born with a "natural level" of cholesterol. What is natural for one person may not be enough for another. But, doctors are dumping statins indiscriminately in a misguided attempt to bring everyone's natural level of cholesterol down to some artificially low level.